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Similarly, 4-hydroxybenzaldehyde shows selective brain distribution, with the highest concentration in the striatum of normal rats (Cmax = 0.074 μg/mL) and significantly increased cortical exposure (AUC = 0.696 mg/mL·h) with prolonged retention (t 1 / 2 β = 22.73 h) in MCAO/R models, suggesting ischemia enhances its brain targeting (Mi et al., 2020)

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The important side chain nucleophiles (in order from most to least nucleophilic) are Cys (RSH, pKa 8 \) summarizes nucleophilic addition and substitution at carbonyl carbons