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Maca, scientifically known as Lepidium meyenii , is a biennial herbaceous plant belonging to the cruciferous family, which also includes broccoli, cabbage, and kale

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The lead analogue, RgIA-5524, incorporating a methylene thioacetal in loop II, demonstrated potent inhibition of human α9α10 nAChRs (IC 50 = 0.9 nM), exceptional selectivity across a wide range of pain-associated ion channels and receptors, and significantly improved serum stability by preventing disulfide scrambling