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Interestingly, prominent hydrogen bonds, formed between the generated amine groups of Metro with the carbonyl oxygen of C P and the amine group of Metro-P3 with carbonyl oxygen of Ser54, provide a rationale for the inhibition of HpTpx red solely by the reduced ligands, explaining why the nitro-prodrugs cannot act as inhibitors of HpTpx

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10.1016/j.biocel.2012.06.009 [DOI] [PubMed] [Google Scholar] Eisenhauer B., Natoli S., Liew G., Flood V