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In adults Macrogol 3350 with potassium chloride, sodium bicarbonate and sodium chloride may be used as detailed below, although this is considered outside the scope of its licence: g dose titration schedule for faecal impaction ▶ l l IMPORTANT SAFETY INFORMATION MHRA/CHM ADVICE: POLYETHYLENE GLYCOL (PEG) LAXATIVES AND STARCH-BASED THICKENERS: POTENTIAL INTERACTIVE EFFECT WHEN MIXED, LEADING TO AN INCREASED RISK OF ASPIRATION (APRIL 2021) Addition of a macrogol (PEG)-based laxative to a liquid that has been thickened with a starch-based thickener may counteract the thickening action, resulting in a thin watery liquid that, when swallowed, increases the risk of potentially fatal aspiration in patients with dysphagia