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That's a significant oversight, because the organ that may benefit most from creatine isn't the one you're training on leg day

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In addition, reduced lysosomal acidification and autophagic–lysosomal network function may be involved owing to mutant presenilin 1-driven deficits in maturation and translocation of vacuolar-type H + -ATPase complex (v-ATPase) subunits to the lysosome