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In addition, the Connectivity Map gene profiling software developed by the Broad Institute, showed that out of several thousand biological molecules, the naturally occurring peptide glycyl-L-histidyl-L-lysine (GHK), in its Cu-bound form prevented impaired TGFβ1 signaling [4], a pathway associated with Aβ deposition and neurofibrillary tangle formation [5]
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Several studies of stroke have demonstrated that signal pathways regulate AQP4 expressions, such as the MAPK pathway and NF-κB pathway (Qi et al., 2011
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