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In comparison analysis the researchers found: “Although the individual study demonstrated a short-term positive response regarding pain control and swelling reduction, the pooled analysis did not find any clinical benefit of intraarticular hyaluronic acid injection following ACLR surgery.” A January 2023 study ( 3 ) looked at the data of 951 patients over 12 previously published studies and found in patients who had hyaluronic acid injections following arthroscopic knee surgery, including ACL reconstruction, “the available evidence does not support its efficacy in pain relief and functional recovery

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Figure 1 shows the biological function of melatonin in circadian rhythm regulation