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First, a role for the MRP proteins in GSH transport was indicated by studies in the yeast Saccharomyces cerevisiae (Rebbeor et al., 1998a, 1998b, 2002), and in membrane vesicles isolated from the liver of the little skate, Leucoraja erinacea (Rebbeor et al., 2000) or from yeast and from rat liver (Rebbeor et al., 2002)

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Usually, GPx requires GSH in millimolar concentrations in the intracellular space, and plasma GSH reaches micromolar concentrations, which questions GPx’s antioxidant function [135]