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This work shows that the stabilized stem subunit could be a potential antigen for a SARS-CoV-2 universal vaccine against unpredictable variants.” The study found immunization with the stem induced balanced Immunoglobulin G (IgG) antibodies with potent and broad ADCC activity, a type of immune reaction in which infected cells are coated with antibodies that then recruit certain types of white blood cells to kill the infected cells