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56,57 At least 25 serotonergic drugs are metabolised by the cytochrome P450 pathway, 19 and a recent study has shown that 50% of the top 20 drugs associated with SS have known pharmacokinetic interactions in which coadministration of cytochrome P-450 inhibitors may elevate drug concentrations to toxic levels

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In that trial, short-term treatment with anti-CD122 inhibited IFN-γ production by TRMs, and long-term use depleted these cells from the lesions.88 Additional IL15 functions have also been mapped in other studies