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In the tMCAO model, L-lactate treatment can ameliorate neurological deficits after ischemia by inducing sustained neuroprotection for up to two weeks ( In the human and rodent traumatic brain injury (TBI) model, evidence shows that endogenous produced brain L-lactate or exogenous L-lactate replenishment can facilitate neurologic recovery by improving synaptic plasticity (109) and regulating the brain metabolic state (76, 110–114) (see section “TBI”)

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