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A recent study revealed that MSCs secrete various chemokine (C-X-C motif) ligands and chemokine (C-C motif) ligands, vascular endothelial growth factor A, and IL-6 under the exposure of synovial fluid from patients with early- and late-stage OA

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Further in vitro studies illustrated that intra-articular injection of exosomes derived from ESC-MSCs successfully alleviated cartilage destruction by increasing collagen type II synthesis and decreasing ADAMTS-5 expression, which exerted a beneficial therapeutic effect on OA [78]