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Too much sumoylation is thought to be one cause of ALS.[ref] Increasing sumoylation increases EAAT2 on the cell membrane of the astrocyte, causing more glutamate to be taken from the synapse into the astrocyte.[ref] ↑ Sumoylation = ↓ EAAT2 on cell membrane = ↑ glutamate toxicity S-nitrosylation is the process of attaching a nitroso group (-NO) to a molecule
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