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This “PK-PD disconnect” is compatible with a peptide whose mechanism triggers downstream signalling cascades (VEGFR2 activation, fibroblast migration, angiogenesis) that persist well beyond direct peptide presence

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Thus, if we know the temperature of one object (call it a thermometer), and it is in thermal equilibrium with water around it, which will occur after enough time has passed, we also know the temperature of the water