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Additionally, the long-term safety and tolerability of CDDO-ME for CKD patients are being estimated by the EAGLE study (phase III, 2019–2024, These clinical trials are based on the profound function of Nrf2 in renoprotection, and reducing oxidative stress by Nrf2 activation is expected to mitigate a variety of diseases beyond kidney disease

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According to NICE Clinical Knowledge Summary guidance, patients with neurological involvement should receive more intensive initial treatment to optimise recovery potential