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Rapamycin (sirolimus) and FK506 (tacrolimus) are two PPI stabilizing molecules that interact directly with FKBP12 immunophilin (Vellanki et al., 2020) (Table 5)
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Kellner-Weibel et al., 1999), including the onset of cardiovascular disease (Steinberg, 2002) as well as neurodegenerative diseases like Alzheimer’s (Paul et al., 2017)
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