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Biased activation GPCRs are dynamic and interact with various effectors, including G-proteins (G s , G i/o , G 11/q , and G 12/13 ) and arrestins (e.g., β-arrestin1 and β-arrestin2), to mediate distinct physiological effects

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IGF-1 has highest affinity for the IGF-1R (Steele-Perkins et al., 1988) with much lower affinity for IGF-2R and the IR