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Solution turns cloudy after initial clarity A solution that was clear after reconstitution but turns cloudy during storage typically indicates protein aggregation due to temperature excursion (the vial got too warm or too cold) or bacterial contamination

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Results: When applied for perioperative stroke prediction among 44,901 patients undergoing noncardiac surgery, the EACH score achieved an area under the curve (AUC) of 0.829 (95% CI 0.753-0.892)