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UPR represents the predominant signaling pathway that is initiated in response to ERS
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NNMT knockdown in mouse adipocytes significantly increased intracellular NAD + levels, silencing NNMT in HT-29 cells led to a 30% rise of NAD + levels approximately, whereas NNMT overexpression in SW480 cells led to a 30% decrease in intracellular NAD + levels [44, 45]
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