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Figure A.9.1—Hazard Categories for Specific Target Organ Toxicity Following Repeated Exposure CATEGORY 1 : Substances that have produced significant toxicity in humans, or that, on the basis of evidence from studies in experimental animals can be presumed to have the potential to produce significant toxicity in humans following repeated or prolonged exposure Substances are classified in Category 1 for specific target organ toxicity (repeated exposure) on the basis of: (a) reliable and good quality evidence from human cases or epidemiological studies