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Glutathione Together with glutaredoxins (Grx), GSH acts to reduce disulfide bonds and is, in turn, oxidized to glutathione disulfide (GSSG), which is reduced by NADPH-dependent glutathione reductase

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To assess the differences in the prevalence of driver mutations between tumour and model samples, we first curated a set of driver genes based on previous TCGA studies 106 (Supplementary Table 10)