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health insurance resulted in a high narrow-sense heritability (h 2 = 0.48) ( 2 to be 0.08 with a low confidence ( Some polymorphisms in genes related to the immunomodulatory response have been identified ( There are also genetic predispositions that render certain individuals susceptible to developing autoimmune diseases ( Viral triggers and reactivation As in other chronic diseases, ME/CFS involves an asymptomatic predisposition stage, then a prodromal stage, followed by symptomatic disease ( Figure 4