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439 Combination of H1-antihistamines and nasal corticosteroids Conceptually, it is meaningful to use both nasal corticosteroids and local nasal antihistamines at the same time, because such treatment can block the main cause of direct response and reduce inflammation through significantly different mechanisms

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In addition to DAMPs, pathogen-associated molecular patterns such as viral RNA or the bacterial cell wall component lipopolysaccharide (LPS) may also maintain neuroinflammation