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Fucoidan-selenium nanoparticles (FD-SeNPs) induced ferroptosis in hepatocellular carcinoma cells through downregulation of the Nrf2/HO-1 and SLC7A11/GSH/GPX4 pathways, characterized by elevated ROS, MDA, and Fe 2+ levels, reduced GSH, mitochondrial shrinkage and cristae disruption, upregulation of ferroportin, and downregulation of SLC40A1 and Ferritin, ultimately disrupting iron homeostasis (Chen et al., 2025a)

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10.1016/j.cell.2017.10.011 [DOI] [PubMed] [Google Scholar] Rüb U., Stratmann K., Heinsen H., Seidel K., Bouzrou M., Korf H