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PMID: 42065240 J Exp Clin Cancer Res The G Protein Estrogen Receptor (GPER) is involved in the resistance to the CDK4/6 inhibitor palbociclib in breast cancer

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Although exact mechanisms are still unclear, CBD may inhibit endocannabinoid signaling and its effects on synaptic plasticity through negative allosteric modulation [83], while the enhancement of vasopressin and oxytocin release by CBD and other epigenetic modulations have also been proposed [78,84]