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The combination of microneedles and tacrolimus ointment showed more prominent therapeutic effects, suggesting that although blank microneedles can treat vitiligo, monotherapy with microneedles may have limited efficacy and longer treatment cycles.Further studies have confirmed that, compared to monotherapy with microneedles, combining microneedles with other treatments can significantly shorten the treatment course and improve repigmentation rates
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Combined exposure to ethanol and palmitoleic acid (POA) increases intracellular and mitochondrial ROS in AR42J pancreatic cells that results in a significant increase in the necroptosis mediator receptor-interacting protein and mixed lineage kinase domain-like pseudokinase
