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(Robert Gauthier / Los Angeles Times) Jose Esquivel flags down motorists to visit a parking lot full of donated clothes, supples, water and brisket in Refugio, Texas

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The mechanism sits upstream of anything you can feel: blocking NNMT stops nicotinamide being methylated into 1-MNA, which raises intracellular NAD+ and SAM and suppresses fat-cell lipogenesis

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