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In addition, SeC@PA MN(+) significantly increased the levels of the anti-inflammatory factors IL-4 and IL-10 and decreased those of the pro-inflammatory factors IL-1 and TNF-α, further demonstrating that macrophages were polarized to the M2- phenotype (Fig

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However, further studies and more conclusive evidence are needed to consolidate the link between hypersulfhydration and DS-related symptoms