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This research topic aims at gathering reviews and research articles on, but not limited to, the following themes: - Mechanisms that underlie adipocyte differentiation and its regulation - Effect of adipocyte released factors on different cells/organs - New molecules targeting adipocytes and affecting their function - New signaling pathways involved in adipocyte signaling and function - New insights on adipocyte pluripotency and adipose-derived mesenchymal stem cells molecular actions - Molecular mechanisms of adipocytes cross-talk with different cell types In contrast to the classical view, considering adipose tissue to be an inert organ for storing energy as fat, it is now well acknowledged that adipose tissue is actually one of the largest and most dynamic organs, playing pivotal roles in the regulation of energy homeostasis