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Main pathway: G-actin sequestration Native Tβ4 binds monomeric G-actin with a dissociation constant (KD) of approximately 1 µM, controlling the pool of free actin available for polymerization into F-actin (actin filaments)
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However, the production of IL-1β during the GA process is puzzling, with studies reporting that MSU crystals alone do not participate in the transcription of IL-1β but only in the regulation of the conversion of inactive IL-1β to an activated state (10, 11)
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