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Sensitive Skin Models Tolerability Data in Research Sensitive skin is broadly defined by a lowered neurogenic threshold: sensory nerve fibers in the epidermis fire more readily in response to physical, chemical, and osmotic stimuli, producing stinging, burning, or flushing responses that do not correlate with visible inflammation

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Sustained systemic inhibition across multiple tissues in a healthy adult is a pharmacological action whose long-term consequences have not been studied in humans