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In AD transgenic mice, curcumin administration downregulates hippocampal expression of HMGB1, RAGE, TLR4, and NF-κB, improving cognitive function by suppressing the HMGB1-RAGE/TLR4-NF-κB inflammatory signaling cascade (Thota et al., 2020)

Designs for Health

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Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine