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Peter Attia, MD—a longevity and wellness expert and host of the The Drive podcast— discusses this in detail in his blog post, Lean mass loss on GLP-1 receptor agonists: a downside of the “miracle drugs.” He discusses how Ozempic causes both muscle and fat loss and does not improve body composition as much as natural weight loss methods

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Amycretin , Novo Nordisk’s oral GLP-1/amylin receptor agonist, showed 13.1% weight loss at 12 weeks in a small Phase I/II trial