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This molecular specificity makes LC-MS indispensable for mapping the metabolic fates of boron carriers and identifying LAT1-dependent biomarkers predictive of BNCT response

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Despite this caveat, compound 25 exhibits potent antitumor activities in multiple animal models and synergistically inhibits tumor survival with chemotherapeutic agents (Figure 2B) 46 , confirming that inhibiting SCF SKP2 is potentially beneficial for cancer patients