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58,59 demonstrated that downregulation of IFN-sensitive gene expression by interference with STAT-1 methylation can promote interaction with the protein inhibitor of activated STATs (PIAS)
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Moreover, the increase in GSH levels induced by Nrf2 activation prevents the p75 NTR -mediated apoptosis of neurons in vitro ( In our mouse model, BSO and iAs up-regulated NGF protein levels in plasma although in the case of iAs, at a delayed time scale (Figure 1) that was not associated with TrkA activation in the striatum (Figure 3)
