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Restriction of iron for cancer cell growth can be accomplished by mobilizing or inhibiting iron delivery by transferrin, mobilizing iron from the intracellular LMWt iron pool, from the iron storage proteins ferritin and hemosiderin, and by inhibiting the turnover of related enzymes such as ribonucleodite reductase and cyclo-oxygenase [60,61,62,129,130,131,132]