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Preclinical studies suggest that statins can reduce BBB permeability by enhancing the expression of tight junction proteins and decreasing the activity of MMPs, which are implicated in the degradation of tight junctions (Liu et al., 2021)

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In 2011, Kakkar and Kaur introduced spanlastics, a non-immunogenic, biodegradable system that delivers medications via various routes, including oral, topical, nasal, and transdermal methods 29