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The immunoprotective role of CO in cancer has been implemented in a study developing a cancer nanovaccine using soft X-ray-triggered CO releasing lanthanide scintillator nanoparticles (ScNPs: NaLuF 4 :Gd,Tb@NaLuF 4 ) combination with a PhotoCORM, which has demonstrated promise in reversing the immunosuppressive TME, activating the adaptive anti-tumor immunity, and therefore causing systemic tumor growth inhibition through ROS generation and the induction of immunogenic cell death (Li, Jiang et al