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Moreover, 4E-BP expression in Drosophila muscles is able to improve systemic proteostasis and promote lifespan extension (Demontis and Perrimon, 2010), in line with a later mouse study showing that 4E-BP1 activity in muscles influences organismal metabolism during aging (Tsai et al., 2015)

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Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans