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Under cellular stress, p53 induces expression of the pro-apoptotic protein Bax, leading to mitochondrial membrane disruption, cytochrome c release, and subsequent activation of Caspase-3, thereby amplifying apoptotic cell death
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Thus, Pyridoxine affects the biosynthesis and concentration of several neurotransmitters such as dopamine, norepinephrine, 5 hydroxytryptamine, histamine, and GABA
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