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The mature T cell immunological synapse contains two distinct, stable membrane domains: a central cluster of T cell receptors, called the central supramolecular activation cluster (cSMAC), and a surrounding adhesive ring that incorporates LFA1, called the peripheral supramolecular activation cluster (pSMAC)

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Moreover, human midbrain neurons show heightened sensitivity to erastin-induced ferroptosis compared with other death stimuli, and the iron chelator deferiprone mitigates dopaminergic degeneration in animal models while improving motor function in PD patients