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This study demonstrated that different analogs have variable abilities to bind HGF, and that the analogs showing antagonism to HGF are acting as a Hinge mimics D-Nle-X-Ile-NH—(CH 2 ) 5 —CONH 2 derivatives were found to compete with Hinge for HGF binding and exhibited a range of affinities for HGF, with K i s ranging from 1.37×10 −7 -1.33×10 −10 M ( 26 , 27 )