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The direct contact of OLs with T cells has been suggested to induce OL damage, and anti-ICAM-1 antibodies were found to inhibit Th1 cell contact with OLs [187]

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Conversely, S6K1-mediated mSIN1 phosphorylation inhibits mTORC2, representing a negative feedback loop that may be disrupted in tumors [43,44]

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