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Similar limitations affect MAPK-targeted therapy: although BRAF and MEK inhibitors have shown substantial benefit, especially in BRAF V600-mutant melanoma, monotherapy often leads to rapid resistance driven mainly by ERK reactivation

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Thioredoxin redox regulates ATPase activity of magnesium chelatase CHLI subunit and modulates redox-mediated signaling in tetrapyrrole biosynthesis and homeostasis of reactive oxygen species in pea plants