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Mechanistically, the antioxidant capacity of OSR is largely attributed to its ability to induce and stabilize GPX4, a selenium‑dependent enzyme that neutralizes lipid peroxides and serves as a central safeguard against ferroptotic cell death 25,26 .Mechanistic analyses revealed that OSR promotes GPX4 expression at both the transcriptional and translational stages and engages in direct binding with GPX4, validated through computational docking and CETSA experiments
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Pyrimidine synthesis and homocysteine remethylation are essential for DNA stability and DNA repair
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