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IKKβ becomes S-glutathionylated upon exposure to ROS, thereby deactivating kinase activity and leading to reduced NF-κB signaling ( 3.2 MAPK pathway The MAPK signaling pathway constitutes a pivotal component within the eukaryotic signal transmission network, serving as a primary conduit for cellular processes such as proliferation, differentiation, apoptosis, and stress response under both normal and pathological conditions ( H 2 O 2 -induced apoptosis by reducing intracellular ROS levels and counteracting the actions of Ha-Ras ( The JNK signal transduction pathway represents a vital branch within the MAPK pathway
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