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Furthermore, it has been found that β-carotene significantly increases maximum voluntary contraction, with mechanisms potentially involving the promotion of protein synthesis, improvement of energy metabolism, and reduction of oxidative damage (122)

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Molecular dynamics (MD) simulations, mass spectrometry and E194A site-directed mutagenesis revealed that PARP1-mediated ribosylation of PXR E194 enhanced CYP3A4 transcription, ultimately leading to excessive NAPQI production