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Relative Contraindications and Cautions require careful consideration: History of pancreatitis : While not an absolute contraindication, patients with prior pancreatitis have increased risk of recurrence

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Under normal unstressed conditions, KEAP1 binds to NRF2 and facilitates its degradation via the ubiquitin‐proteasome pathway, which is crucial for maintaining NRF2 at low levels [77]