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In these cases, ɑ-synuclein mRNA was not expression in the liver, suggesting that this deposition travels to the liver via the PNS or circulatory systems (Reyes et al., 2021)

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Copper deficiency impairs mitochondrial respiration, antioxidant defense, and vascular structural integrity, whereas copper overload triggers oxidative stress, inflammatory responses, and aberrant activation of cell death signaling