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However, research links testosterone therapy with several complications, such as: an increased risk of cardiovascular disease an increased risk of venous thrombosis, or blood clots reduced sperm count, which can persist in 10% of maleseven after stopping testosterone therapy Testosterone is not suitable or safe for people with: prostate cancer a history of breast cancer gynecomastia and other breast disorders unmanaged heart failure unmanaged obstructive sleep apnea a history of cardiovascular events in the last 6 months undiagnosed prostate nodules plans to conceive in the near future Some potential side effects of testosterone include: bruising, pain, bleeding, or swelling at the injection site prostate enlargement weight gain increased appetite hot flushes acne depression restlessness or irritability aggression tiredness or weakness excessive sweating If testosterone levels get too high, a person may have more serious symptoms, such as signs of liver toxicity